Does Abilify Lead to Weight Gain?

Post written by BH Staff Writer on January 1, 1970
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Aripiprazole, known commercially as Abilify, is an atypical antipsychotic prescribed for individuals who haven’t seen significant improvements with other antidepressants. While some patients report weight gain while on Abilify, the evidence supporting this isn’t particularly strong. Is weight gain a genuine side effect or merely a myth? Let’s explore this further.

Does Abilify Cause Weight Gain?

In short, YES.

Different factors may contribute to weight gain in association with Abilify, and these can vary from person to person.

Here are several ways Abilify might influence your weight:

  • Enhanced appetite.
  • Increased blood sugar levels.
  • Slowed metabolism.
  • Side effects that reduce activity levels, affecting exercise and dietary habits.
  • More noticeable weight gain when combined with other medications.
  • Improved mood potentially leading to increased food intake.

What Is Abilify?

Abilify, created by Bristol-Myers Squibb, is an atypical antipsychotic medication targeting specific brain chemicals, making it effective for various depressive disorders.

Since its FDA approval in 1999, Abilify has been used to treat major depressive disorder, bipolar I disorder, and general anxiety disorder. Additionally, it’s used off-label for conditions like autism, epilepsy, and binge eating disorder (BED).

How Does Abilify Work?

Abilify impacts essential brain chemicals that regulate mood, such as norepinephrine (noradrenaline), dopamine, serotonin, and gamma-aminobutyric acid (GABA).

These chemicals act as neurotransmitters, helping neurons communicate. In individuals with depression, the balance of these neurotransmitters can be disrupted. Medications like Abilify strive to rebalance these chemical levels.

How Much Weight Might You Gain on Abilify?

Although weight gain can occur with Abilify, the extent varies based on factors like dosage, duration of use, other medications, and initial body weight. Patients have reported weight gains ranging from 2.2 lbs (1 kg) to as much as 90 lbs (40 kg).

How Can You Avoid Weight Gain While Taking Abilify?

If you’re experiencing significant weight gain with Abilify, it’s important to consult your doctor. Here are some strategies to manage or prevent weight gain:

  • Follow a balanced diet, control portion sizes, and reduce sugary and high-fat food intake.
  • Regularly monitor your weight to detect gradual increases.
  • Engage in daily physical activity for at least one to two hours.
  • Discuss potential dosage adjustments with your doctor.
  • Consider switching to another medication upon your doctor’s advice.
  • If taking Abilify with another antidepressant, consider switching to bupropion, which has less impact on serotonin receptors.
  • Explore adding Topamax (topiramate) at a low dose to manage weight gain.

If you have more questions or need further support, consider contacting Bridge Health for personalized guidance in managing your medication and overall health.

Always consult your healthcare provider before making any changes to your medication regimen. Your doctor’s expertise is crucial in finding the most suitable treatment plan for your specific needs.

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