Lispro insulin is a fast-acting insulin treatment designed to manage hyperglycemia commonly associated with both Type 1 and Type 2 diabetes. This peptide hormone mimics the effects of natural human insulin and plays a critical role in glucose metabolism, produced by the beta cells of the pancreas.
The pancreas secretes insulin to facilitate glucose absorption into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Furthermore, insulin inhibits hepatic glucose production, enhances protein synthesis, and prevents both lipolysis and proteolysis.
Understanding the Peak of Insulin Lispro
Insulin Lispro is a modified form of human insulin, designed to be absorbed more rapidly and have a shorter duration of effect than traditional insulin.
Here are the key points about Insulin Lispro’s action:
- Onset within 0 to 15 minutes post-administration
- Peaks between 30 to 90 minutes
- Duration of effect is less than five hours
This means Insulin Lispro can be administered 15 minutes before a meal. It provides an advantage over conventional insulin, which must be given 30 minutes prior to eating, especially if a meal is missed or delayed, thereby reducing the risk of hypoglycemia.
Production Process of Insulin Lispro
Insulin Lispro is a genetically modified insulin analog, featuring a specific alteration where the amino acid proline at B-28 is replaced by lysine at B-29.
This modification allows the insulin to dissolve more rapidly into dimers and monomers, leading to faster absorption when injected subcutaneously.
Besides lowering blood sugar levels like other insulin types, Insulin Lispro offers additional benefits:
- Quicker subcutaneous absorption
- Higher and earlier peak insulin levels
- Faster decline after peaking
Note: There is also an Insulin Lispro protamine suspension formula that acts for a longer duration. Humalog 75:25 combines Insulin Lispro protamine suspension (intermediate-acting insulin) with Insulin Lispro (rapid-acting insulin).
For more detailed guidance and support, you can visit our trusted partner, Bridge Health.