Humulin vs Humalog: In-Depth Comparison and Primary Distinctions

Post written by BH Staff Writer on April 29, 2022
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When comparing Humulin and Humalog, it’s crucial to understand the key differences related to their applications, types, and potential side effects.

**Definitions**

[Humulin](https://bridgecanhealth.com/shop/insulin-humulin-n-kwikpen-3-ml/) is a synthetic insulin designed to compensate for the pancreas’s inadequate natural insulin production. This essential hormone plays a critical role in blood sugar regulation.

[Humulin](https://bridgecanhealth.com/shop/insulin-humulin/) comes in various forms, including [Humulin R](https://bridgecanhealth.com/shop/insulin-humulin-n-kwikpen-3ml/), [Humulin N](https://bridgecanhealth.com/shop/insulin-humulin-n-vial-100u-ml/), as well as Humulin 70:30 and Humulin 50:50. These versions are chiefly used by individuals managing type 2 diabetes.

On the other hand, Humalog is a synthetic insulin analog, primarily used to control blood sugar spikes in people with type 2 diabetes. It is typically injected 15 minutes before or after meals.

**Usage**

Humulin, also referred to as insulin isophane, acts relatively quickly, entering the bloodstream and initiating its action around 30 minutes after injection. Conversely, Humalog works even faster, starting its effect within approximately 15 minutes of administration.

**Types of Humulin**

The different types of Humulin include:

  • Humulin R: A short-acting insulin that begins working within 30 minutes post-injection, with effects lasting up to 8 hours.
  • Humulin N: An intermediate-acting insulin that starts its action 2 to 4 hours after injection and can last up to 18 hours.
  • Humulin 70:30 / Humulin 50:50: These formulations mix short-acting and intermediate-acting insulin.

**Types of Humalog**

The varieties of Humalog include:

  • Insulin Lispro: A rapid-acting insulin that takes effect within 15 minutes of injection and remains active for 2 to 4 hours.
  • Humalog Mix: A combination insulin containing protamine to slow insulin absorption.

**Side Effects of Humulin and Humalog**

As both Humulin and Humalog are forms of insulin, they share common side effects, such as:

  • Hypoglycemia (low blood sugar levels)
  • Unexplained weight gain
  • Vision issues
  • Muscle pain
  • Muscle cramps
  • Irregular heartbeat
  • Mood changes
  • Hypokalemia (low potassium levels)
  • Skin rashes (typically at the injection site)
  • Scarring at the injection site

If you’re allergic to either medication, it is imperative to avoid them and consult your healthcare provider for safer treatment options.

**Takeaway**

Both Humulin and Humalog are typically administered via injection. If not provided in vials, they come in pre-filled pens. When using vials, ensure you use a clean and sterilized syringe to extract the insulin.

**Sources**:

[Learn more about the differences between Humulin and Humalog here.](https://insulinoutlet.com/information/what-is-the-difference-between-humulin-and-humalog/)

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